Reimer-Tiemann Reaction
About Reimer-Tiemann Reaction
An alkaline solution of phenol is refluxed with chloroform at 60°C, distilling off the excess of chloroform and acidifying the residual liquid with sulphuric acid. As a result, o-hydroxy and p-;hydroxy benzaldehyde are formed, which are separated by steam-distillation.
Reaction Mechanism of Reimer-Tiemann Reaction
If ‘o’ both the o-positions are blocked, p-hydroxy benzaldehyde is the main product. With blocked p-position, o-hydroxy benzaldehyde and cyclohexadienones are formed.
Cyclohexadienone derivative remains unhydrolysed as it has a neopentylic system, which involves lot of steric crowding.
When phenol is refluxed with CCl4 in alkaline medium, salicylic acid is formed.
Example of Reimer-Tiemann Reaction
List of Name Reaction of Organic Chemistry consist of detail Reaction Mechanism of all name reactions of Organic Chemistry.
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